Endocrine Abstracts

Background: A 23-year-old woman diagnosed with Dunnigan-type familial partial lipodystrophy (FPLD) attended the joint Antenatal/Endocrine Clinic at 13 weeks of gestation. She was diagnosed at age 7 and subsequently developed type 2 diabetes at age 11 years. She was managed initially with metformin followed by addition of insulin. It was an unplanned pregnancy and her booking HbA1c was 8.4% (IFCC 68 mmol/mol).Prior to pregnancy, she was on a basal bolus r...

Case history: A 60-year-old male underwent left sided orchidectomy for a Seminoma in November 2005. As a part of work up for the Seminoma, he was noted to have bilateral adrenal masses which raised the possibility of metastasis.Investigations: CT scan of the abdomen showed 22 mm mass on the right with a Hounsfield units of −31 and a 12 mm mass on the left with Hounsfield units of −1. The radiological phenotype of these masses along with densi...

A 74 year old lady presently to casualty with generalized ill health, vomiting and a mechanical fall. She was well known to the psychiatry team with severe depressive disorder managed with Lithium. Clinical examination was unremarkable. Baseline blood tests confirmed hyperparathyroidism with corrected calcium of 3.24 mmol/l and high parathyroid hormone levels of 13.4 pmol/L. Lithium levels were normal. She improved clinically with intravenous hydration followed by pamidronate ...

A 68 years old lady was referred to our endocrine clinic after she had routine blood tests done as a part of monitoring of her chronic kidney disease stage 3. She had high corrected calcium of 2.85 mmol/l and parathyroid hormone levels of 13 pmol/l consistent with primary hyperparathyroidism. She was clinically symptomatic with high calcium and had polyuria, polydipsia and constipation. There was no history of renal calculi or fractures although DEXA scan confirmed osteoporosi...

A 60 years old man was referred to the ENT department with a three week history of swelling in the left parotid gland region. Examination revealed a firm mass involving the left parotid gland. Fine needle aspiration cytology of the mass raised the suspicion of a malignancy. MRI scan of head and neck was consistent with metastatic involvement of the ipsilateral lymph glands. He underwent left radical neck dissection and left parotidectomy. Histology confirmed adenocarcinoma of ...

Hypoglycemia during hospital admission remains a common complication of diabetes. Hypoglycemia is associated with increased morbidity and mortality, increased length of stay, increased admission rate and increased cost to the NHS. Prompt treatment of inpatient hypoglycemia is imperative to avoid such complications. The Hypoglycemia box is an important tool to manage hypoglycemia on the wards. It is crucial for all clinical members to be aware of the hypoglycemia box; its conte...

Hypophysitis is an inflammatory disorder of the pituitary gland and among them, IgG-4 hypophysitis is rare and presents in less than 5 % of cases.Case: 59 years old lady with a past medical history of asthma presented Rheumatology with? giant cell arthritis due to constant frontal headache, pain behind her eyes, and raised inflammatory markers (ESR 15, CRP 17) three weeks after COVID infection. After review, rheumatology team concluded unlikely giant cel...

A 52 year old man presented 5 years ago with a history of persistent rhinorrhea, blocked nose and epistaxis. MR scanning revealed blockage of the ethmoid sinus with polypoidal material extending into the nasopharynx, anterior cranial fossa and right orbit. He had craniofacial resection of the lesion and histology confirmed an olfactory neuroblastoma.He represented in 2005 with a two-week history of generalized weakness, lack of energy, and bilateral ankl...

Introduction: Crooke’s cell adenomas are nonneoplastic corticotropes with cytoplasmic accumulation of cytokeratin filaments in response to glucocorticoid excess. They are rare subtype of corticotrope adenomas presenting less than 1 % of pituitary adenomas.Case: 52 years old man attended Ophthalmology Clinic with 2 months history of right-sided reduced vision. He had a history of posterior polymorphous corneal dystrophy with a left corneal transplant...

A 46 years old gentleman was referred by his GP to cardiology with 3 weeks history of bilateral leg swelling and rash associated with breathlessness and palpitations. He has no other past medical history to note. He smokes 20 cigarettes a day and works as a manager in a window installation company. He was started on diuretics and further investigations were arranged by cardiology. His symptoms persisted with worsening of skin rash. He was reviewed by GP again 1 month later. He...